1-Methyl-4-[2-nitro-4-(trifluoromethyl)phenyl]piperazine → 2-(4-Methylpiperazin-1-yl)-5-(trifluoromethyl)aniline

HRID 1361588Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1361588
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=2[N+:18]([O-])=O)[CH2:4][CH2:3]1>CO.[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:15])[F:16])=[CH:10][C:9]=2[NH2:18])[CH2:6][CH2:7]1

Komponenten

4

Edukt 1

HCID 28607241-Methyl-4-[2-nitro-4-(trifluoromethyl)phenyl]piperazine

Produkt 1

HCID 6932882-(4-Methylpiperazin-1-yl)-5-(trifluoromethyl)aniline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To 1-Methyl-4-(2-nitro-4-trifluoromethyl-phenyl)-piperazine (1.46 g, 5.05 mmol) in dry MeOH (50 mL) was added Pd/C (10%, 535 mg). H2 gas was bubbled through the solution at room temperature overnight with vigorous stirring. The reaction mixture was filtered through celite to provide, after concentration, the desired product as a white solid. MS (M+H)+=260; Calc'd 259.28 for C12H16F3N3.

Aufarbeitung

  1. customH2 gas was bubbled through the solution at room temperature overnight with vigorous stirring
  2. filtrationThe reaction mixture was filtered through celite
  3. customto provide
  4. concentrationafter concentration

Quellen und Nachweise

ORD-Eintrag
ord-964508dd143b4f2792d6daa4671bb2dc
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07880000B2

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