Piperidine → 5-Bromo-3-piperidin-1-ylmethyl-pyridin-2-ylamine

HRID 1362097

Reaktionsgleichung

Reaktionsgleichung von HRID 1362097
Br.[Br:2][C:3]1[CH:4]=[C:5]([CH2:10]Br)[C:6]([NH2:9])=[N:7][CH:8]=1.[NH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>CC#N.CCOCC>[Br:2][C:3]1[CH:4]=[C:5]([CH2:10][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[C:6]([NH2:9])=[N:7][CH:8]=1

Komponenten

5

Edukt 2

HCID 8082PiperidineHCID 534200525-Bromo-3-(bromomethyl)pyridin-2-amine hydrobromide

Produkt 1

HCID 594569835-Bromo-3-piperidin-1-ylmethyl-pyridin-2-ylamineAusbeute 53,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

An ice-cold suspension of 5-bromo-3-bromomethyl-pyridin-2-ylamine hydrobromide (10.0 g, 28.8 mmol) in MeCN (100 mL) was treated with piperidine (6.4 mL, 64.8 mmol). After stirring at room temperature for 3.5 h, the mixture was diluted with Et2O (500 mL). The solution was filtered and then concentrated to give the title compound (4.16 g, 53%) as a pale, yellow solid: MS (ESI) m/e 270 (M+H)+.

Aufarbeitung

  1. filtrationThe solution was filtered
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-7b1adbb30ca24a069da8dc51c1197c74
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07879872B2

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