Hydrochloric Acid → 2-Amino-N-(2-hydroxyethyl)benzamide

HRID 1362851Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1362851
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6]C(=O)[O:4][C:2]2=O.[CH2:13]([CH2:15][NH2:16])[OH:14].Cl>O>[NH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[C:2]([NH:16][CH2:15][CH2:13][OH:14])=[O:4]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 700EthanolamineHCID 8359Isatoic Anhydride

Produkt 1

HCID 30164842-Amino-N-(2-hydroxyethyl)benzamideAusbeute 71,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A round-bottomed flask was charged with isatoic anhydride (5.0 g, 0.030 mol) and 40 mL water. Ethanolamine (2.21 mL, 0.036 mol) was added slowly to the reaction mixture. The reaction mixture was acidified with 1N HCl and extracted with EtOAc. The aqueous layer was basified with 6N NaOH and extracted with EtOAc. The EtOac layer was dried over Na2SO4, filtered, and concentrated to dryness to afford 2-amino-N-(2-hydroxyethyl)benzamide (3.86 g, 70%).

Aufarbeitung

  1. extractionextracted with EtOAc
  2. extractionextracted with EtOAc
  3. dry with materialThe EtOac layer was dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-615327560ff240ffb23ce3103b92f713
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07884098B2

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