Pyridinium chloride → (+)-trans-5,7-Dihydroxy-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-2-(4-trifluoromethyl-phenyl)-chromen-4-one

HRID 1363355Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1363355
[OH:1][CH2:2][C@H:3]1[C@H:7]([C:8]2[C:9]([O:31]C)=[CH:10][C:11]([O:29]C)=[C:12]3[C:17]=2[O:16][C:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)=[CH:14][C:13]3=[O:28])[CH2:6][CH2:5][N:4]1[CH3:33].Cl.N1C=CC=CC=1>>[OH:29][C:11]1[CH:10]=[C:9]([OH:31])[C:8]([C@@H:7]2[CH2:6][CH2:5][N:4]([CH3:33])[C@H:3]2[CH2:2][OH:1])=[C:17]2[C:12]=1[C:13](=[O:28])[CH:14]=[C:15]([C:18]1[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=1)[O:16]2

Komponenten

3

Edukt 2

HCID 10176127Pyridinium chlorideHCID 66933632(+)-trans-8-(2-Hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-2-(4-trifluoromethyl-phenyl)-chromen-4-one

Produkt 1

HCID 66933731(+)-trans-5,7-Dihydroxy-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-2-(4-trifluoromethyl-phenyl)-chromen-4-one

Versuchsvorschrift

Compound of example 64 (0.7 g, 1.51 mmol) was demethylated using pyridine hydrochloride (7 g, 60.60 mmol) as described in example 17 to obtain the title compound.

Quellen und Nachweise

ORD-Eintrag
ord-e4f19ee5eaf841a5be02ea5837097e75
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07884127B2

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