Reaktionsgleichung
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][NH:8][C:7](=[O:11])[N:6]=1)(=[O:3])[CH3:2].S(=O)(=O)(O)O.[F:17][C:18](I)([F:20])[F:19].OO>S([O-])([O-])(=O)=O.[Fe+2].CS(C)=O>[C:1]([NH:4][C:5]1[C:10]([C:18]([F:20])([F:19])[F:17])=[CH:9][NH:8][C:7](=[O:11])[N:6]=1)(=[O:3])[CH3:2]Komponenten
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 45 °C
Versuchsvorschrift
0.15 g (1.0 mmol) of N4-acetylcytosine was weighed and placed in a 50 ml two-neck flask equipped with a magnetic rotor and the atmosphere in the flask was replaced with argon. The following materials were added thereinto: 17 ml of dimethyl sulfoxide, 2.0 ml of a 1N dimethyl sulfoxide solution of sulfuric acid, 1.0 ml of a 3.0 mol/l dimethyl sulfoxide solution of trifluoromethyl iodide, 0.2 ml of a 30% hydrogen peroxide aqueous solution and 0.3 ml of a 1.0 mol/l aqueous solution of iron (II) sulfate. The mixture was stirred at 40 to 50° C. for 20 minutes and then the resulting solution was cooled to room temperature. Formation of N4-acetyl-5-trifluoromethylcytosine (19F-NMR yield: 35%) was confirmed by 19F-NMR with 2,2,2-trifluoroethanol as an internal standard. N4-acetyl-5-trifluoromethylcytosine was obtained as a white solid (0.067 g, yield: 30%) by column chromatography.
Aufarbeitung
- customplaced in a 50 ml two-neck flask
- customequipped with a magnetic rotor
- additionThe following materials were added
- temperaturethe resulting solution was cooled to room temperature
Quellen und Nachweise
- ORD-Eintrag
- ord-71ff73e34a6f428d955a5441e069a9b1
- Quelldatensatz
- uspto-grants-2011_02
- Patentnummer
- US07884202B2
Verknüpfte Notizen
Wird geladen…