HCID 4715295, Verbindung → 2-ethylbenzenepropanoic acid
Reaktionsgleichung
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]=[CH:10][C:11]([OH:13])=[O:12])[CH3:2]>C1COCC1.[Pd]>[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH3:2]Komponenten
4
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
3-(2-Ethyl-phenyl)-acrylic acid (17.00 g, 96.48 mmol) in THF was mixed with Pd/C (1.50 g) and hydrogenated at 50 psi for 6 hours. The resulting mixture was filtered through a pad of celite and the filtrate was concentrated to give 3-(2-ethyl-phenyl)-propionic acid. The acid was reacted with SOCl2 (5.00 mL, 68.55 mmol) and AlCl3 (6.70 g, 50.25 mmol) according to the protocols as outlined in general procedure C to give the title compound.
Aufarbeitung
- filtrationThe resulting mixture was filtered through a pad of celite
- concentrationthe filtrate was concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-1b287ec0f60747dd8b8169f7cf9f4a92
- Quelldatensatz
- uspto-grants-2011_02
- Patentnummer
- US07884244B2
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