m-Aminoacetanilide → {2-[3-(3-Acetylamino-phenyl)-3-cyclohexylmethyl-ureido]-thiazol-5-ylsulfanyl}-acetic acid
Reaktionsgleichung
C([O:3][C:4](=[O:33])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([NH:29][C:30](=[O:32])[CH3:31])[CH:24]=2)[CH2:16][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:14])=[N:9][CH:8]=1)C.C1(CN(C2C=CC(F)=C(F)C=2)C(=O)NC2SC=C(CC(O)=O)N=2)CCCC1.NC1C=C(NC(=O)C)C=CC=1.C(OC(=O)CSC1SC(N)=NC=1)C>>[C:30]([NH:29][C:25]1[CH:24]=[C:23]([N:15]([CH2:16][CH:17]2[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]2)[C:13](=[O:14])[NH:12][C:10]2[S:11][C:7]([S:6][CH2:5][C:4]([OH:33])=[O:3])=[CH:8][N:9]=2)[CH:28]=[CH:27][CH:26]=1)(=[O:32])[CH3:31]Komponenten
5
Edukt 4
Produkt 1
Versuchsvorschrift
The title compound was prepared via {2-[3-(3-acetylamino-phenyl)-3-cyclohexylmethyl-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(3,4-difluoro-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using N-(3-amino-phenyl)-acetamide, cyclohexylcarbaldehyde and (2-amino-thiazol-5-ylsulfanyl)acetic acid ethyl ester.
Quellen und Nachweise
- ORD-Eintrag
- ord-5c442f429230475f9fc5052b398ba9cb
- Quelldatensatz
- uspto-grants-2011_02
- Patentnummer
- US07884210B2
Notizen zur Reaktion
Wird geladen…