3-Methoxyacetophenone → (+-)-1-(3-Methoxyphenyl)ethanol

HRID 1364407

Reaktionsgleichung

Reaktionsgleichung von HRID 1364407
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH3:11])[CH:5]=1)=[O:3].[BH4-].[Na+].[Cl-].[NH4+]>CO>[CH3:11][O:10][C:6]1[CH:5]=[C:4]([CH:2]([OH:3])[CH3:1])[CH:9]=[CH:8][CH:7]=1

Komponenten

5

Edukt 3

HCID 114603-MethoxyacetophenoneHCID 25517Ammonium ChlorideHCID 4311764Sodium borohydride

Produkt 1

HCID 90902(+-)-1-(3-Methoxyphenyl)ethanolAusbeute 86,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 3-methoxyacetophenone (3 g; 20 mmol) in methanol (60 mL) is added sodium borohydride (1.13 g; 30 mmol) in four portions over one hour. The reaction is stirred at room temperature overnight, neutralized with saturated ammonium chloride, and extracted with ethyl acetate. The organics are separated, washed with water, and dried over magnesium sulfate. The solvent is removed to give 2.62 grams of 1-(3-methoxyphenyl)-ethanol.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. customThe organics are separated
  3. washwashed with water
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent is removed

Quellen und Nachweise

ORD-Eintrag
ord-349df5ab7597479883ecf1d6154bd7e0
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07888366B2

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