Hydrochloric Acid → HCID 66924212, Verbindung

HRID 1364449Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1364449
[Sn](Cl)Cl.Cl.[Cl:5][C:6]1[CH:24]=[CH:23][C:9]([O:10][CH2:11][C:12]2[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-])=O)[C:13]=2[C:14]#[N:15])=[CH:8][C:7]=1[CH3:25].[OH-].[K+]>>[NH2:20][C:16]1[CH:17]=[CH:18][CH:19]=[C:12]([CH2:11][O:10][C:9]2[CH:23]=[CH:24][C:6]([Cl:5])=[C:7]([CH3:25])[CH:8]=2)[C:13]=1[C:14]#[N:15]

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 24479Stannous ChlorideHCID 66924453HCID 66924453, Verbindung

Produkt 1

HCID 66924212HCID 66924212, VerbindungAusbeute 88,9 %

Reaktionsbedingungen

Temperatur
15 °C

Versuchsvorschrift

To a cooled (15° C.) and stirred solution of tin (II) chloride (0.37 g, 1.65 mmol) and con. hydrochloric acid (2.0 mL) was added a solution of 2-(4-chloro-3-methylphenoxymethyl)-6-nitrobenzonitrile (100.0 mg, 0.33 mmol). The reaction mixture was slowly warmed to room temperature and stirred for 3 hours. The reaction mixture was poured on to crushed-ice and potassium hydroxide solution, stirred, extracted with dichloromethane, filtered and dried to yield 80 mg of 2-amino-6-(4-chloro-3-methylphenoxymethyl)benzonitrile.

Aufarbeitung

  1. temperatureThe reaction mixture was slowly warmed to room temperature
  2. additionThe reaction mixture was poured on
  3. stirringstirred
  4. extractionextracted with dichloromethane
  5. filtrationfiltered
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-78bcf64c888e4afa9d94837fec22bd2b
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07888366B2

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