Hydrochloric Acid → HCID 24777029, Verbindung

HRID 1364456Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1364456
[Sn](Cl)Cl.Cl.[F:5][C:6]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:7]=1[O:8][CH2:9][C:10]1[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-])=O)[C:11]=1[C:12]#[N:13].[OH-].[K+]>>[NH2:18][C:14]1[CH:15]=[CH:16][CH:17]=[C:10]([CH2:9][O:8][C:7]2[CH:21]=[CH:22][C:23]([F:25])=[CH:24][C:6]=2[F:5])[C:11]=1[C:12]#[N:13]

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 24479Stannous ChlorideHCID 24776912HCID 24776912, Verbindung

Produkt 1

HCID 24777029HCID 24777029, VerbindungAusbeute 91,5 %

Reaktionsbedingungen

Temperatur
15 °C

Versuchsvorschrift

To a cooled (15° C.) and stirred solution of tin (II) chloride (0.37 g, 1.65 mmol) and con. hydrochloric acid (2.0 mL) was added a solution of 2-(2,4-difluorophenoxymethyl)-6-nitrobenzonitrile (160.0 mg, 0.55 mmol). The reaction mixture was slowly warmed to room temperature and stirred for 3 hours. The reaction mixture was poured on to crushed-ice and potassium hydroxide solution, stirred, extracted with dichloromethane, filtered and dried to yield 131 mg of 2-amino-6-(2,4-difluorophenoxymethyl)benzonitrile.

Aufarbeitung

  1. temperatureThe reaction mixture was slowly warmed to room temperature
  2. additionThe reaction mixture was poured on
  3. stirringstirred
  4. extractionextracted with dichloromethane
  5. filtrationfiltered
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ab1b91f807b441d49e1d3e1813658753
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07888366B2

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