2-Methoxy-1-phenylethanone → 2-Methoxy-1-phenylethan-1-ol

HRID 1364481Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1364481
[CH3:1][O:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[BH4-].[Na+]>C(O)C>[CH3:1][O:2][CH2:3][CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[OH:5]

Komponenten

4

Edukt 2

HCID 776982-Methoxy-1-phenylethanoneHCID 4311764Sodium borohydride

Produkt 1

HCID 5722942-Methoxy-1-phenylethan-1-olAusbeute 78,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a stirred solution of 2-methoxy-1-phenylethanone (1.0 g, 6.66 mmol) in ethanol was added sodium borohydride (0.28 g, 7.32 mmol). The reaction mixture was stirred at room temperature for 1 hour. The reaction mixture was quenched with sat. ammonium chloride solution, concentrated. Extracted with ethyl acetate, washed with brine, dried, and concentrated to yield 0.8 g of 2-methoxy-1-phenylethanol.

Aufarbeitung

  1. customThe reaction mixture was quenched with sat. ammonium chloride solution
  2. concentrationconcentrated
  3. extractionExtracted with ethyl acetate
  4. washwashed with brine
  5. customdried
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-6e2bde9bd215416492fcfa59e9a45d5b
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07888366B2

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