Morpholine → 4-((4-(Bromomethyl)phenyl)sulfonyl)morpholine

HRID 1364585

Reaktionsgleichung

Reaktionsgleichung von HRID 1364585
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1.C(N(CC)CC)C.[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>ClCCl.Cl>[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)(=[O:11])=[O:10])=[CH:5][CH:4]=1

Komponenten

6

Edukt 3

HCID 8083MorpholineHCID 8471TriethylamineHCID 27344094-(Bromomethyl)benzenesulfonyl chloride

Produkt 1

HCID 27796804-((4-(Bromomethyl)phenyl)sulfonyl)morpholine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a stirring solution of commercially-available 4-bromomethyl benzenesulfonyl chloride (1.0 g, 3.71 mmol) in dichloromethane (8 ml) at 0° C. under an argon atmosphere, is added triethylamine (0.575 ml, 4.1 mmol), in one portion, followed by morpholine (0.359 ml, 4.1 mmol). The reaction mixture is stirred for 20 h, warming up slowly to room temperature. The reaction mixture is then diluted with 2N HCl aq (40 ml) and extracted in dichloromethane (20 ml), dried (MgSO4) and evaporated to dryness in vacuo to afford the title compound. No mass ion detected.

Aufarbeitung

  1. extractionextracted in dichloromethane (20 ml)
  2. dry with materialdried (MgSO4)
  3. customevaporated to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1e89f22503134cad9b9f17ec320c3ec8
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07888383B2

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