N,N,N',N'-Tetramethylethylenediamine → Methyl 3-((tert-butoxycarbonyl)amino)furan-2-carboxylate

HRID 1365125

Reaktionsgleichung

Reaktionsgleichung von HRID 1365125
[O:1]1[CH:5]=[CH:4][C:3]([NH:6][C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:2]1.CN(CCN(C)C)C.C([Li])CCC.[C:27](=O)([O:30]C)[O:28][CH3:29]>C1COCC1>[CH3:29][O:28][C:27]([C:2]1[O:1][CH:5]=[CH:4][C:3]=1[NH:6][C:7](=[O:13])[O:8][C:9]([CH3:10])([CH3:12])[CH3:11])=[O:30]

Komponenten

6

Edukt 4

HCID 8037N,N,N',N'-TetramethylethylenediamineHCID 12021Dimethyl CarbonateHCID 12207186tert-butyl N-(furan-3-yl)carbamateHCID 178418339Butyllithium

Produkt 1

HCID 52987670Methyl 3-((tert-butoxycarbonyl)amino)furan-2-carboxylateAusbeute 51 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a solution of tert-butyl furan-3-ylcarbamate 32 (1.7 g, 1.0 eq) in THF (50 ml) at −30° C. was added TMEDA (1.75 ml, 1.3 eq) followed by 1.6M solution of n-butyllithium (8.4 ml, 2.25 eq, 1.6M in hexanes). Reaction mixture was allowed to warm up to 0° C. and stirred for 1 h, before being cooled back to −30° C. Dimethyl carbonate (2.4 ml, 3.0 eq) was quickly added, before the reaction mixture was allowed to warm up to room temperature for 1 hr. Reaction mixture was quenched with 2M HCl, followed by addition of saturated aq. NaCl. Mixture was extracted with ethyl acetate. The combined organic extracts were dried with Na2SO4 and concentrated. The crude reaction mixture was purified by flash chromatography to yield tert-butyl 2-(methoxycarbonyl)furan-3-ylcarbamate 33 (1.14 g, 51%): MS (Q1) 242 (M)+.

Aufarbeitung

  1. customReaction mixture
  2. temperaturebefore being cooled back to −30° C
  3. temperatureto warm up to room temperature for 1 hr
  4. customReaction mixture
  5. customwas quenched with 2M HCl
  6. additionfollowed by addition of saturated aq. NaCl
  7. extractionMixture was extracted with ethyl acetate
  8. dry with materialThe combined organic extracts were dried with Na2SO4
  9. concentrationconcentrated
  10. customThe crude reaction mixture
  11. customwas purified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-a0bf178147f146f18554b3de636500d4
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07888352B2

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