Sodium hydride → 4-(2-Methoxy-ethoxy)-1-(3-methoxy-4-nitro-phenyl)-piperidine

HRID 1366286Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1366286
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:12]2[CH2:17][CH2:16][CH:15]([OH:18])[CH2:14][CH2:13]2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].[H-].[Na+].[CH3:21][O:22][CH2:23][CH2:24]Br.[Cl-].[NH4+]>CN(C)C=O.O>[CH3:21][O:22][CH2:23][CH2:24][O:18][CH:15]1[CH2:16][CH2:17][N:12]([C:5]2[CH:6]=[CH:7][C:8]([N+:9]([O-:11])=[O:10])=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:13][CH2:14]1

Komponenten

7

Edukt 4

HCID 24758Sodium hydrideHCID 25517Ammonium ChlorideHCID 809722-Bromoethyl methyl etherHCID 259188601-(3-Methoxy-4-nitrophenyl)piperidin-4-ol

Produkt 1

HCID 587485624-(2-Methoxy-ethoxy)-1-(3-methoxy-4-nitro-phenyl)-piperidineAusbeute 29,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 1-(3-Methoxy-4-nitro-phenyl)-piperidin-4-ol (300 mg, 1.2 mmol) in N,N-dimethylformamide (3.0 mL), sodium hydride (1.52 g, 3.8 mmol) is added. After stirring, 2-bromoethyl methyl ether (150 μl, 1.6 mmol) is added and the mixture is further stirred at 70° C. for 15 hours. After addition of saturated aqueous ammonium chloride, the mixture is poured into water and extracted twice with ethyl acetate. The organic layer is washed with brine, dried over sodium sulfate, and evaporated in vacuo. The residue is purified by silica gel column chromatography (n-hexane-ethyl acetate gradient) to afford 4-(2-Methoxy-ethoxy)-1-(3-methoxy-4-nitro-phenyl)-piperidine (111 mg, 29%) as a yellow oil.

Aufarbeitung

  1. stirringthe mixture is further stirred at 70° C. for 15 hours
  2. extractionextracted twice with ethyl acetate
  3. washThe organic layer is washed with brine
  4. dry with materialdried over sodium sulfate
  5. customevaporated in vacuo
  6. customThe residue is purified by silica gel column chromatography (n-hexane-ethyl acetate gradient)

Quellen und Nachweise

ORD-Eintrag
ord-da1ec44cfdc74f0a9a2264fcd469e448
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07893074B2

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