Diisopropylethylamine → (R)-1-(6-Iodo-3-methanesulfonyl-2-methyl-quinolin-4-yl)-piperidin-3-ol

HRID 13664Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 13664
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([I:12])[CH:10]=2)[N:5]=[C:4]([CH3:13])[C:3]=1[S:14]([CH3:17])(=[O:16])=[O:15].[OH:18][C@@H:19]1[CH2:24][CH2:23][CH2:22][NH:21][CH2:20]1.C(N(CC)C(C)C)(C)C>CN(C)C=O>[I:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[C:4]([CH3:13])[C:3]([S:14]([CH3:17])(=[O:16])=[O:15])=[C:2]2[N:21]1[CH2:22][CH2:23][CH2:24][C@@H:19]([OH:18])[CH2:20]1

Komponenten

5

Edukt 3

HCID 81531DiisopropylethylamineHCID 27593343-Hydroxypiperidine, (R)-HCID 120016244-Chloro-6-iodo-3-methanesulfonyl-2-methyl-quinoline

Produkt 1

HCID 12001808(R)-1-(6-Iodo-3-methanesulfonyl-2-methyl-quinolin-4-yl)-piperidin-3-olAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

4-Chloro-6-iodo-3-methanesulfonyl-2-methyl-quinoline (compound of example D.2) (300 mg, 0.786 mmol), (R)-(+)-3-hydroxypiperidine (119 mg, 0.865 mmol) and N,N-diisopropyl ethyl amine (0.148 mL, 0.865 mmol) were heated in dry N,N-dimethylformamide (3 mL) for 0.5 h at 100° C. N,N-Dimethylformamide was evaporated at 40° C./0.1 mbar, the residue was extracted with dichloromethane and 10% Na2CO3, and then purified by chromatography on silica gel in dichloromethane/methanol 20:1. One obtained a yellow oil which was triturated with ethyl acetate and the resulting white crystals were filtered off. One obtained 209 mg (60%) of white crystals. MS: m/z=447 (M+H).

Aufarbeitung

  1. customN,N-Dimethylformamide was evaporated at 40° C./0.1 mbar
  2. extractionthe residue was extracted with dichloromethane and 10% Na2CO3
  3. custompurified by chromatography on silica gel in dichloromethane/methanol 20:1
  4. customOne obtained a yellow oil which
  5. customwas triturated with ethyl acetate
  6. filtrationthe resulting white crystals were filtered off

Quellen und Nachweise

ORD-Eintrag
ord-600ea43f320240e58a7342bd9fbc75b3
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728142B2

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