Acetic Acid → HCID 178475354, Verbindung

HRID 1368522

Reaktionsgleichung

Reaktionsgleichung von HRID 1368522
O[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([C:17]1[N:18]=[CH:19][N:20](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:21]=1)([OH:16])[CH:13]([CH3:15])[CH3:14])[CH:6]=[CH:5]2.N1C=CC=CC=1.[C:47]([OH:50])(=[O:49])[CH3:48]>>[C:47]([O:50][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([C:17]1[N:18]=[CH:19][NH:20][CH:21]=1)([OH:16])[CH:13]([CH3:15])[CH3:14])[CH:6]=[CH:5]2)(=[O:49])[CH3:48]

Komponenten

4

Edukt 3

HCID 176Acetic AcidHCID 1049PyridineHCID 220183856-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthol

Produkt 1

HCID 178475354HCID 178475354, Verbindung

Versuchsvorschrift

A mixture of 1-(6-hydroxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (1.0 g), pyridine (4 ml) and anhydrous acetic acid (4 ml) was stirred at room temperature for 14 h. The reaction mixture was concentrated to dryness, and the residue was dissolved in ethyl acetate and washed with water and saturated aqueous solution of sodium chloride. The solution was dried and concentrated. The residue was crystallized from ethyl acetate-diisopropyl ether to give the titled compound (0.6 g) as a colorless powder.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated to dryness
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washwashed with water and saturated aqueous solution of sodium chloride
  4. customThe solution was dried
  5. concentrationconcentrated
  6. customThe residue was crystallized from ethyl acetate-diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-4c6348e8c0ec41f5a301822bcf38763d
Quelldatensatz
uspto-grants-2003_06
Patentnummer
US06573289B1

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