HCID 22018328, Verbindung → HCID 178466003, Verbindung

HRID 1368541Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1368541
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[CH:10]=[C:9]([C:14]([C:19]1[N:20]=[CH:21][N:22](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:23]=1)([OH:18])[CH:15]([CH3:17])[CH3:16])[CH:8]=[CH:7]2)[CH3:2]>C(O)(=O)C.[C].[Pd]>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[CH:10]=[C:9]([C:14]([C:19]1[N:20]=[CH:21][NH:22][CH:23]=1)([OH:18])[CH:15]([CH3:17])[CH3:16])[CH:8]=[CH:7]2)[CH3:2]

Komponenten

4

Edukt 1

HCID 22018328HCID 22018328, Verbindung

Produkt 1

HCID 178466003HCID 178466003, VerbindungAusbeute 62,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

1-(6-Ethoxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (0.60 g) was dissolved in acetic acid (10 ml). To the solution was added 10% palladium carbon (0.2 g), and the mixture was stirred under hydrogen atmosphere at 50° C. for 2 h then at 60° C. for 3 h. The catalyst was filtered off, filtrate was concentrated to dryness. Recrystallization from THF-ethyl acetate gave the titled compound (0.21 g) as a colorless powder.

Aufarbeitung

  1. waitat 60° C. for 3 h
  2. filtrationThe catalyst was filtered off
  3. concentrationfiltrate was concentrated to dryness
  4. customRecrystallization from THF-ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-e5a224b9f2bf452c881f18952c6300dc
Quelldatensatz
uspto-grants-2003_06
Patentnummer
US06573289B1

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