Hydrochloric Acid → HCID 178493936, Verbindung

HRID 1368778

Reaktionsgleichung

Reaktionsgleichung von HRID 1368778
Cl.[NH2:2][C:3]([NH2:5])=[NH:4].[O-]CC.[Na+].[CH3:10][O:11][CH:12]([C:17](OC)=[O:18])[C:13](OC)=[O:14].Cl>C(O)C>[NH2:4][C:3]1[N:5]=[C:17]([OH:18])[C:12]([O:11][CH3:10])=[C:13]([OH:14])[N:2]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 5742Guanidine HydrochlorideHCID 78718Dimethyl methoxymalonateHCID 2723922Sodium ethoxide

Produkt 1

HCID 178493936HCID 178493936, VerbindungAusbeute 20,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture composed of 12 g of guanidine hydrochloride, 9 g of sodium ethoxide and 100 ml of ethanol was heated under reflux for 1 hour, and then the reaction solution was cooled to room temperature, further mixed with 10 g of dimethyl methoxymalonate and heated under reflux for 48 hours. The reaction solution was cooled to room temperature, adjusted to a pH value of about 4 by adding 1 N hydrochloric acid solution and stirred, and then the thus precipitated powder was collected by filtration to obtain 2.0 g of the title compound.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 1 hour
  3. temperatureheated
  4. temperatureunder reflux for 48 hours
  5. temperatureThe reaction solution was cooled to room temperature
  6. filtrationthe thus precipitated powder was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-84d371195f7d4e7f89a35111ab491ef2
Quelldatensatz
uspto-grants-2003_06
Patentnummer
US06573377B1

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