Acetic Acid → 2-Bromo-1-methoxymethyl-3-methylbenzene

HRID 1369592

Reaktionsgleichung

Reaktionsgleichung von HRID 1369592
[Br:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[C:11](=O)(O)[O-:12].[Na+].C(O)(=O)C>CO>[Br:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][O:12][CH3:11]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 516892Sodium BicarbonateHCID 109343202-Bromo-1-(bromomethyl)-3-methylbenzene

Produkt 1

HCID 138434542-Bromo-1-methoxymethyl-3-methylbenzeneAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a stirred solution of 2-bromo-3-methylbenzylbromide (5.2 g, 0.0197 mol) in methanol (30 ml) was added saturated sodiumbicarbonate (5 ml) and the mixture was refluxed overnight. The mixture was neutralised with acetic acid and the solvent was evaporated under reduced pressure. Chromatography of the residue on silica gel using hexane:methylene chloride (7/3) as eluent gave 4.2 g (99%) of the title compound.

Aufarbeitung

  1. temperaturethe mixture was refluxed overnight
  2. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-71cb6ed385944d218490145813e7eb64
Quelldatensatz
uspto-grants-2003_06
Patentnummer
US06579884B1

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