Imidazo(1,2-a)pyrazin-8-amine, 3-bromo-N-methyl- → N-Methylimidazo[1,2-A]pyrazin-8-amine
Reaktionsgleichung
Br[C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[C:10]([NH:11][CH3:12])[C:5]2=[N:4][CH:3]=1>CO.[Pd]>[N:4]1[CH:3]=[CH:2][N:6]2[CH:7]=[CH:8][N:9]=[C:10]([NH:11][CH3:12])[C:5]=12Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To a solution of (3-bromo-imidazo[1,2-a]pyrazin-8-yl)-methyl-amine (Example 1) (2.4 g, 11.9 mmol) in methanol (160 ml) was added Pd-C (10% wt. 0.1 eq). The mixture was hydrogenated at rt overnight, filtered, and washed with hot methanol. The organics were combined and concentrated to afford 2.8 g of crude imidazo[1,2-a]pyrazin-8-yl-methyl-amine (M).
Aufarbeitung
- filtrationfiltered
- washwashed with hot methanol
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-2472619a08234b0a870c8ef98436cd41
- Quelldatensatz
- uspto-grants-2007_01
- Patentnummer
- US07157460B2
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