Pyrrolidine → 2-[3-(pyrrolidin-1-ylsulfonyl)propyl]-1H-isoindole-1,3(2H)-dione

A solution of 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propane-1-sulfonyl chloride (0.288 g) in dry tetrahydrofuran (5 ml) was treated with N,N-diisopropylethylamine (0.350 ml) and pyrrolidine (0.10 ml) at 22° C. under nitrogen, and the mixture was stirred at 22° C. for 1 h. After standing overnight at room temperature, the mixture was partitioned between saturated aqueous sodium bicarbonate (10 ml) and ethyl acetate (2×10 ml). The organic layers were washed with brine, dried (MgSO4) and evaporated in vacuo to give a white solid (0.145 g).

1. waitAfter standing overnight at room temperature
2. customthe mixture was partitioned between saturated aqueous sodium bicarbonate (10 ml) and ethyl acetate (2×10 ml)
3. washThe organic layers were washed with brine
4. dry with materialdried (MgSO4)
5. customevaporated in vacuo

ORD-Eintrag

ord-ba8c723901e04e50846e4c072c9b295c

Quelldatensatz

uspto-grants-2007_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07157457B2