HCID 21070648, Verbindung → HCID 21070645, Verbindung

HRID 1371771Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1371771
[N:1]([CH:4]1[CH2:9][CH2:8][N:7]([S:10]([CH3:13])(=[O:12])=[O:11])[CH2:6][CH:5]1[O:14][CH3:15])=[N+]=[N-]>C(O)C.[Pd]>[CH3:13][S:10]([N:7]1[CH2:8][CH2:9][CH:4]([NH2:1])[CH:5]([O:14][CH3:15])[CH2:6]1)(=[O:12])=[O:11]

Komponenten

4

Edukt 1

HCID 21070648HCID 21070648, Verbindung

Produkt 1

HCID 21070645HCID 21070645, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

The azide (270 mg, 1.15 mmol, Example 311) in ethanol was hydrogenated at 40 psi under the catalysis of palladium on carbon for 1 hour. The mixture was filtered and the filtrate was concentrated to give an off-white solid. 230 mg, 96%. It was used directly for the next step.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. customto give an off-white solid

Quellen und Nachweise

ORD-Eintrag
ord-dd01abf6e98843dabb75f0b200a57d0e
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07157455B2

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