Trifluoroacetic acid → 5-Fluoro-2-[5-(hexahydro-1,4-diazepin-1-yl)pyrazin-2-yl-carbonylamino]-N-(5-chloropyridin-2-yl)benzamide

HRID 1372877

Reaktionsgleichung

Reaktionsgleichung von HRID 1372877
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[N:16]=[CH:17][C:18]([C:21]([NH:23][C:24]3[CH:39]=[CH:38][C:37]([F:40])=[CH:36][C:25]=3[C:26]([NH:28][C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][N:30]=3)=[O:27])=[O:22])=[N:19][CH:20]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl.C1(OC)C=CC=CC=1>[F:40][C:37]1[CH:38]=[CH:39][C:24]([NH:23][C:21]([C:18]2[CH:17]=[N:16][C:15]([N:11]3[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]3)=[CH:20][N:19]=2)=[O:22])=[C:25]([CH:36]=1)[C:26]([NH:28][C:29]1[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][N:30]=1)=[O:27]

Komponenten

5

Edukt 2

HCID 6422Trifluoroacetic acidHCID 111806062-[5-(4-t-Butoxycarbonylhexahydro-1,4-diazepin-1-yl)pyrazin-2-ylcarbonylamino]-5-fluoro-N-(5-chloropyridin-2-yl)-benzamide

Produkt 1

HCID 98693075-Fluoro-2-[5-(hexahydro-1,4-diazepin-1-yl)pyrazin-2-yl-carbonylamino]-N-(5-chloropyridin-2-yl)benzamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 7519AnisoleLösungsmittel

Versuchsvorschrift

To a suspension of 2-[5-(4-t-butoxycarbonylhexahydro-1,4-diazepin-1-yl)pyrazin-2-ylcarbonylamino]-5-fluoro-N-(5-chloropyridin-2-yl)benzamide (Example P1, 11.4 g) in methylene chloride (30 mL) and anisole (10 mL) was added trifluoroacetic acid (30 mL) dropwise. The mixture was stirred overnight at room temperature before the solvent was evaporated. The residue was purified by using an SCX column. Yield 8.1 g.

Aufarbeitung

  1. customwas evaporated
  2. customThe residue was purified

Quellen und Nachweise

ORD-Eintrag
ord-6a6db8c1d7d345a7925ee6236819d89b
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07160878B2

Verknüpfte Notizen

Wird geladen…