Sodium Iodide → 4-Iodomethyl-5-methyl-2-naphthalen-2-yloxazole

HRID 1373159Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1373159
Cl[CH2:2][C:3]1[N:4]=[C:5]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)[O:6][C:7]=1[CH3:8].[I-:19].[Na+].C(OC)(C)(C)C>CC(C)=O>[I:19][CH2:2][C:3]1[N:4]=[C:5]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)[O:6][C:7]=1[CH3:8]

Komponenten

5

Edukt 3

HCID 5238Sodium IodideHCID 15413tert-Butyl methyl etherHCID 121580734-(Chloromethyl)-5-methyl-2-(naphthalen-2-yl)-1,3-oxazole

Produkt 1

HCID 210742684-Iodomethyl-5-methyl-2-naphthalen-2-yloxazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

1.8 g of 4-chloromethyl-5-methyl-2-naphthalen-2-yloxazole and 3 g of sodium iodide in 150 ml of acetone are heated under reflux for 2 hours. After the reaction mixture has been cooled, 300 ml of methyl tert-butyl ether are added, the mixture is washed three times with saturated Na2S2O3 solution and dried over MgSO4 and the solvents are then removed under reduced pressure. This gives 2.7 g of 4-iodomethyl-5-methyl-2-naphthalen-2-yloxazole as a light-yellow solid.

Aufarbeitung

  1. temperatureunder reflux for 2 hours
  2. temperatureAfter the reaction mixture has been cooled
  3. washthe mixture is washed three times with saturated Na2S2O3 solution
  4. dry with materialdried over MgSO4
  5. customthe solvents are then removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-fd05c981796b448b8502a53815ae871b
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07160911B2

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