Water → HCID 21072938, Verbindung

Reaktionsgleichung

[CH2:1]([O:3][C:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][CH2:14][CH2:15][CH2:16][C:17]([O:19]CC)=O)=[CH:9][CH:8]=1)=[O:5])[CH3:2].[H-].[Na+].O>O1CCCC1>[CH2:1]([O:3][C:4](=[O:5])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:14][CH2:15][CH2:16][C:17]2=[O:19])=[CH:9][CH:8]=1)[CH3:2]

Komponenten

Versuchsvorschrift

A mixture in tetrahydrofuran (50 ml) of ethyl 4-[4-(ethoxycarbonylmethyl)phenyl]aminobutanoate (2.4 g. 8.3 mmols) and sodium hydride (oily) (0.5 g, 12 mmols) was stirred, while heated under reflux, for 18 hours. The reaction mixture was poured into water, and extracted with ethyl acetate. The extract was washed with brine, and then dried with anhydrous magnesium sulfate. This was concentrated under reduced pressure, and the residue was purified through silica gel column chromatography to give a solid of ethyl[4-(2-oxopyrrolidin-1-yl)phenyl]acetate (1.2 g, 59%).