6-Nitro-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxide → 6-Amino-2,3-dihydro-1,4

HRID 1373719Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1373719
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][CH2:11][CH2:10][S:9](=[O:14])(=[O:13])[C:8]=2[CH:15]=1)([O-])=O.[H][H]>C1COCC1.CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[O:12][CH2:11][CH2:10][S:9](=[O:14])(=[O:13])[C:8]=2[CH:15]=1

Komponenten

6

Edukt 2

HCID 219881646-Nitro-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxideHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 219881516-Amino-2,3-dihydro-1,4Ausbeute 46,4 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

0.917 g 6-Nitro-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxide (from g)) were hydrogenated in a mixture of 20 ml THF and 20 ml MeOH with 0.90 g 5% Pd—C at atmospheric hydrogen pressure for 90 min. at room temperature. The catalyst was filtered off, the filtrate evaporated and the residue chromatographed on silica to yield 370 mg of the title compound.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate evaporated
  3. customthe residue chromatographed on silica

Quellen und Nachweise

ORD-Eintrag
ord-ef96b7afa3474a44a6945b1e95e04c89
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07163941B2

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