Hydrogen Peroxide → 2-tert-Butyl-1-oxo-1lambda~5~-pyridinato

HRID 1374244Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1374244
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH:11]O>CC(O)=O.C(Cl)Cl>[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N+:6]=1[O-:11])([CH3:4])([CH3:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 784Hydrogen PeroxideHCID 1386302-tert-Butylpyridine

Produkt 1

HCID 187150642-tert-Butyl-1-oxo-1lambda~5~-pyridinatoAusbeute 71,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Preparation C3, Step 1: 2-tert-butylpyridine (2.00 g, 14.8 mmol, 1 eq.) was dissolved in HOAc (10 mL) and 30% hydrogen peroxide (1.68 mL, 14.8 mmol, 1 eq.) at room temperature then the reaction was refluxed for 20 hours. The reaction was stripped to obtain an amber oil which was dissolved in methylene chloride (10 mL) then dried over sodium sulfate and stripped to obtain 2-tert-butylpyridine-N-oxide (1.60 g) as an amber oil. Yield=71.5%. LCMS detects (M+H)+=152.09.

Aufarbeitung

  1. customto obtain an amber oil which
  2. dry with materialthen dried over sodium sulfate

Quellen und Nachweise

ORD-Eintrag
ord-51fc4c6ac0ba46bd9f7bff9ec20eb53f
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07163937B2

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