Hexahydro-1H-azepine-1-ethanamine → N-(2-azepan-1-ylethyl)-N-{4-[2-(3-chlorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-yl}amine

HRID 1374730

Reaktionsgleichung

Reaktionsgleichung von HRID 1374730
[N:1]1([CH2:8][CH2:9][NH2:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CS([C:15]1[N:20]=[C:19]([C:21]2[C:22]([C:34]3[CH:39]=[CH:38][CH:37]=[C:36]([Cl:40])[CH:35]=3)=[N:23][N:24]3[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[CH:26][C:25]=23)[CH:18]=[CH:17][N:16]=1)(=O)=O>O>[N:1]1([CH2:8][CH2:9][NH:10][C:15]2[N:20]=[C:19]([C:21]3[C:22]([C:34]4[CH:39]=[CH:38][CH:37]=[C:36]([Cl:40])[CH:35]=4)=[N:23][N:24]4[CH:29]=[C:28]([C:30]([F:33])([F:31])[F:32])[CH:27]=[CH:26][C:25]=34)[CH:18]=[CH:17][N:16]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 40002Hexahydro-1H-azepine-1-ethanamineHCID 179623804-[2-(3-Chlorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-yl methyl sulfone

Produkt 1

HCID 10207930N-(2-azepan-1-ylethyl)-N-{4-[2-(3-chlorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-yl}amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

2-Azepan-1-ylethylamine (0.04 mL) and 4-[2-(3-chlorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-yl methyl sulfone (0.02 g) were mixed at room temperature and heated with an airgun until a homogenous melt was obtained (2 min). Upon cooling, water was added. The precipitated solid was filtered and dried to give the title compound as a beige solid (0.014 g); 1H NMR (d6-DMSO) δ 9.51(1H, s), 8.49(1H, bs), 8.16(1H, d), 7.70–7.65(2H, m), 7.60–7.50(3H, m), 7.00(1H, bs), 6.36(1H, bs), 2.6(6H, bs), 1.6(8H, bs); m/z 515(M+1)+.

Aufarbeitung

  1. temperatureheated with an airgun until a homogenous melt
  2. customwas obtained (2 min)
  3. temperatureUpon cooling
  4. filtrationThe precipitated solid was filtered
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-cb0a0c3edb904cf59a39895d15da4c7b
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07166597B2

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