4,5-Dimethylthiazole → Thiazolium, 3-(2-hydroxy-2-phenylethyl)-4,5-dimethyl-, chloride

HRID 1374926Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1374926
[Cl:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[OH:4].[CH3:11][C:12]1[N:13]=[CH:14][S:15][C:16]=1[CH3:17]>O>[Cl-:1].[C:5]1([CH:3]([OH:4])[CH2:2][N+:13]2[C:12]([CH3:11])=[C:16]([CH3:17])[S:15][CH:14]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Komponenten

4

Edukt 2

HCID 625104,5-DimethylthiazoleHCID 928982-Chloro-1-phenylethanol

Produkt 1

HCID 9838299Thiazolium, 3-(2-hydroxy-2-phenylethyl)-4,5-dimethyl-, chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
135 °C

Versuchsvorschrift

The neat mixture of S (−) 2-chloro-1-phenylethanol (2.78 g., 17.8 mmol) and 4,5-dimethylthiazole (2 g., 17.7 mmol) were heated with stirring at 135° C. for 25 hrs. It was cooled to room temperature and water (30 mL) was added to the reaction mixture with stirring. The solution was extracted with ether (30 mL). The ether extract was again extracted with water (30 mL). The combined water layer was evaporated to dryness and the residue was crystallized with a mixture of acetonitrile and methyl tert-butyl ether. Yield: 0.63 g. (7.7%); mp. 189–190° C.; [α]D25−51.765 (Water, c=1.7732).

Aufarbeitung

  1. temperaturewere heated
  2. temperatureIt was cooled to room temperature
  3. stirringwith stirring
  4. extractionThe solution was extracted with ether (30 mL)
  5. extractionThe ether extract
  6. extractionwas again extracted with water (30 mL)
  7. customThe combined water layer was evaporated to dryness
  8. customthe residue was crystallized with a mixture of acetonitrile and methyl tert-butyl ether

Quellen und Nachweise

ORD-Eintrag
ord-2867466cd7c545319a872be1a2a20212
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07166625B2

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