Thionyl Chloride → HCID 21221127, Verbindung

HRID 1377188Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1377188
[CH3:1][C:2]1[C:9]([CH3:10])=[C:8]([O:11][CH3:12])[CH:7]=[CH:6][C:3]=1[CH2:4]O.C1OC2C=CC(C[Cl:19])=CC=2O1.S(Cl)(Cl)=O>CCOCC>[CH3:1][C:2]1[C:9]([CH3:10])=[C:8]([O:11][CH3:12])[CH:7]=[CH:6][C:3]=1[CH2:4][Cl:19]

Komponenten

5

Edukt 3

HCID 24386Thionyl ChlorideHCID 887131,3-Benzodioxole, 5-(chloromethyl)-HCID 43971742,3-Dimethyl-4-methoxybenzyl alcohol

Produkt 1

HCID 21221127HCID 21221127, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

1 g (6.016 mmol) of 2,3-dimethyl-4-methoxybenzyl alcohol (Aldrich, Steinheim, FRG) and 4.8 g of diisopropylaminomethylpolystyrene (polyhunig base, see Ex. 44a) in 21 ml of abs. ether are treated dropwise, at from 0° C. to 5° C. and over the space of approximately 25 min, with 0.482 ml of thionyl chloride. After the reaction has ended, the mixture is filtered with suction and the solvent and the excess reagent are removed. The residue, which is the desired title compound, is subjected, without purification, to further processing. TLC Rf (hexane:ethyl acetate 4:1)=0.59. IR(CH2Cl2) inter alia: 1599, 1485, 1466 und 1107 cm-1. 1H-NMR (200 MHz, CDCl3): 7.14 (d, 1H); 6.69 (d, 1H); 4.64 (s, 2H); 3.82, 2.34 and 2.18 (each s, each 3H).

Aufarbeitung

  1. filtrationthe mixture is filtered with suction
  2. customthe solvent and the excess reagent are removed
  3. customis subjected, without purification, to further processing

Quellen und Nachweise

ORD-Eintrag
ord-9149e4903598427287ac57559a58efc6
Quelldatensatz
uspto-grants-1997_09
Patentnummer
US05663200

Notizen zur Reaktion

Wird geladen…