Potassium Carbonate → p-Methoxybenzamidoxime

HRID 1377822

Reaktionsgleichung

Reaktionsgleichung von HRID 1377822
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=C(C(F)(F)F)[O:10][N:9]=2)=[CH:4][CH:3]=1.Cl.NO.[C:20](=O)([O-])[O-].[K+].[K+]>C(O)C>[CH3:20][O:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:9][OH:10])[NH2:12])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 1357501134-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenol

Produkt 1

HCID 21471p-MethoxybenzamidoximeAusbeute 20 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

3-(4-hydroxyphenyl)-5-trifluoromethyl-1,2,4- oxadiazole 13.32 g (0.1 mol) 4-methoxybenzonitrile, 20.85 g (0.3 mol) of hydroxylamine hydrochloride and 41.40 g (0.3 mol) potassium carbonate was added to 400 mL absolute ethanol and refluxed 21 hours. The product was filtered and recrystallized from methanol to give 3.12 g (0.02 mol) of 4-methoxybenzamide oxime.

Aufarbeitung

  1. temperaturerefluxed 21 hours
  2. filtrationThe product was filtered
  3. customrecrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-39e0383f481b425b875e46ff219e02b0
Quelldatensatz
uspto-grants-1997_09
Patentnummer
US05665763

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