Methyl Acrylate → 4-Morpholinepropanoic acid, methyl ester

HRID 1379395

Reaktionsgleichung

Reaktionsgleichung von HRID 1379395
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:7]([O:11][CH3:12])(=[O:10])[CH:8]=[CH2:9]>ClCCl>[N:1]1([CH2:9][CH2:8][C:7]([O:11][CH3:12])=[O:10])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 7294Methyl AcrylateHCID 8083Morpholine

Produkt 1

HCID 1013734-Morpholinepropanoic acid, methyl esterAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 4.9 ml (56 mmol) of morpholine in 50 ml of dichloromethane was treated dropwise with 5.0 ml (56 mmol) of methyl acrylate. The resulting solution was allowed to stand at ambient temperature for 3 days, after which it was concentrated in vacuo to an oil. Chromatography on silica gel using 0.5% methanol/2% isopropylamine in chloroform provided 9.54 g (99%) of the desired compound as a colorless liquid.

Aufarbeitung

  1. concentrationafter which it was concentrated in vacuo to an oil

Quellen und Nachweise

ORD-Eintrag
ord-26e81143862744a9b56f0ed9b6f2f8d3
Quelldatensatz
uspto-grants-1997_09
Patentnummer
US05670675

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