Hydrochloric Acid → 4-Nitro-3-(4-methoxyphenyl)heptanedioic acid dimethyl ester

HRID 1380949Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1380949
[CH3:1][O:2][C:3](=[O:18])[CH2:4][CH:5]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)[CH2:6][N+:7]([O-:9])=[O:8].[C:19]([O:23][CH3:24])(=[O:22])[CH:20]=[CH2:21].Cl>C(O)(C)(C)C.C(OCC)C>[CH3:1][O:2][C:3](=[O:18])[CH2:4][CH:5]([C:10]1[CH:11]=[CH:12][C:13]([O:16][CH3:17])=[CH:14][CH:15]=1)[CH:6]([N+:7]([O-:9])=[O:8])[CH2:21][CH2:20][C:19]([O:23][CH3:24])=[O:22]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 7294Methyl AcrylateHCID 54303925Methyl 3-(4-methoxyphenyl)-4-nitrobutanoate

Produkt 1

HCID 537595764-Nitro-3-(4-methoxyphenyl)heptanedioic acid dimethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 6386tert-ButanolLösungsmittel

Versuchsvorschrift

A solution of 200 g of 4-nitro-3-(4-methoxyphenyl)butanoic acid methyl ester, 68 g of methyl acrylate, and 25 ml of Triton B in 500 ml of t-butanol is allowed to stir at room temperature for 94 hours. Excess aqueous hydrochloric acid (1 N) is added and the solution is diluted with diethyl ether. The organic layer is separated, dried over anhydrous magnesium sulfate, and evaporated to give 4-nitro-3-(4-methoxyphenyl)heptanedioic acid dimethyl ester.

Aufarbeitung

  1. customThe organic layer is separated
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-19200836ea4046b3b41791521a3b5c92
Quelldatensatz
uspto-grants-1986_04
Patentnummer
US04584313

Notizen zur Reaktion

Wird geladen…