2-(5-Fluoro-2,4-dinitrophenoxy)acetic acid → 7-Fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-one

HRID 1381640Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1381640
[N+:1]([C:4]1[CH:14]=[C:13]([N+:15]([O-])=O)[C:12]([F:18])=[CH:11][C:5]=1[O:6][CH2:7][C:8](O)=[O:9])([O-])=O.[H][H]>C(O)C.[Pt](=O)=O>[F:18][C:12]1[C:13]([NH2:15])=[CH:14][C:4]2[NH:1][C:8](=[O:9])[CH2:7][O:6][C:5]=2[CH:11]=1

Komponenten

5

Edukt 2

HCID 3028912-(5-Fluoro-2,4-dinitrophenoxy)acetic acidHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 103133897-Fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-oneAusbeute 91,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A suspension of 2,4-dinitro-5-fluorophenoxyacetic acid (0.25 g) and platinum dioxide (80 mg) in ethanol (10 ml) was subjected to catalytic reduction at room temperature under an ordinary pressure until 130 ml of hydrogen was absorbed. The reaction mixture was filtered, and the filtrate was concentrated to give 7-fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-one (0.16 g; yield, 91.4%). M.P., more than 300° C.

Aufarbeitung

  1. customwas absorbed
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-05e29bf0c8854d54a844653f553cc357
Quelldatensatz
uspto-grants-1989_02
Patentnummer
US04803270

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