Triethylamine → 2-Methoxy-8-methylcarbamoyl-2,8-diazaspiro[4,5]decane-1,3-dione

HRID 1381942Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1381942
Cl.[CH3:2][O:3][N:4]1[C:8](=[O:9])[CH2:7][C:6]2([CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[C:5]1=[O:15].C(N(CC)CC)C.[CH3:23][N:24]=[C:25]=[O:26]>O>[CH3:2][O:3][N:4]1[C:8](=[O:9])[CH2:7][C:6]2([CH2:14][CH2:13][N:12]([C:25](=[O:26])[NH:24][CH3:23])[CH2:11][CH2:10]2)[C:5]1=[O:15]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 30882852,8-Diazaspiro(4,5)decane-1,3-dione, 2-methoxy-, monohydrochloride

Produkt 1

HCID 212754282-Methoxy-8-methylcarbamoyl-2,8-diazaspiro[4,5]decane-1,3-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 2-methoxy-2,8-diazaspiro[4,5]decane-1,3-dione hydrochloride (1.5 g) in water (20 ml) was added triethylamine (1 ml), followed by methyl isocyanate (1 ml), and this was followed by stirring at room temperature for 30 minutes. The water was then evaporated off under reduced pressure. The residue was directly subjected to silica gel column chromatography (eluent; chloroform-acetone-methanol=10:3:2 (v/v)), and the solvent for the solution containing the desired product was evaporated off under reduced pressure to obtain 1.4 g of a colorless oily compound.

Aufarbeitung

  1. customThe water was then evaporated off under reduced pressure
  2. additionthe solvent for the solution containing the desired product
  3. customwas evaporated off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-eafad1bcea084cac804c664897443a18
Quelldatensatz
uspto-grants-1989_02
Patentnummer
US04804665

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