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Hydrochloric Acid → 1-(o-Chlorophenoxy)-4-(4-phenyl-1-piperazinyl)-2-butanol

HRID 1382395
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1382395
[Cl:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[O:4][CH:5](Cl)[CH:6]([OH:9])[CH2:7][CH3:8].[C:15]1([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.Cl.[OH-].[Na+]>C(O)(C)C>[Cl:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[O:4][CH2:5][CH:6]([OH:9])[CH2:7][CH2:8][N:24]1[CH2:25][CH2:26][N:21]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:22][CH2:23]1
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 70961-PhenylpiperazineHCID 14798Sodium HydroxideHCID 198402391-(o-Chlorophenoxy)-2-hydroxybutyl chloride

Produkt 1

HCID 131204511-(o-Chlorophenoxy)-4-(4-phenyl-1-piperazinyl)-2-butanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776
Isopropanol
Lösungsmittel

Versuchsvorschrift

A mixture of 35.1 g. (0.15 mole) of 1-(o-chlorophenoxy)-2-hydroxybutyl chloride, 32.6 g. (0.2 mole) of N-phenylpiperazine and 400 ml. of isopropanol was refluxed for 48 hr. The reaction mixture was allowed to stand in a refrigerator overnight and filtered. The filtrate was treated with ethereal hydrogen chloride and the salt precipitated by the addition of ether. The white crystalline solid which formed was dissolved in 0.1 mole of hydrochloric acid and then neutralized with sodium hydroxide producing a crystalline precipitate. This was recrystallized with isopropanol yielding 36 g of the free base of the product which melted at 100°-101.5° C.

Aufarbeitung

  1. additionA mixture of 35.1 g
  2. customto stand in a refrigerator overnight
  3. filtrationfiltered
  4. additionThe filtrate was treated with ethereal hydrogen chloride
  5. customthe salt precipitated by the addition of ether
  6. customThe white crystalline solid which formed
  7. customThis was recrystallized with isopropanol yielding 36 g of the free base of the product which melted at 100°-101.5° C.

Quellen und Nachweise

ORD-Eintrag
ord-3fc405e3cbe747c4b261f0457963d1fb
Quelldatensatz
uspto-grants-1989_02
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04806555

Notizen zur Reaktion

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