Benzamide, N-cyano- → HCID 178512389, Verbindung

HRID 1382446

Reaktionsgleichung

Reaktionsgleichung von HRID 1382446
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)[CH2:4][CH2:3]1.[C:19]([NH:27][C:28]#[N:29])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1(C)C=CC=CC=1>[C:19]([NH:27][C:28]([NH:1][CH:2]1[CH2:3][CH2:4][N:5]([CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)[CH2:6][CH2:7]1)=[NH:29])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Komponenten

4

Edukt 2

HCID 84805Benzamide, N-cyano-HCID 111958234-Amino-1-(2-naphthyl)methylpiperidine

Produkt 1

HCID 178512389HCID 178512389, VerbindungAusbeute 40,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

4-Amino-1-(naphth-2-ylmethyl)piperidine (1.0 g, 0.0042 m) and benzoyl cyanamide (0.67 g, 0.0042 m) in toluene (100 cm3) were refluxed for 15 hours. The solvent was evaporated and the residue recrystallised from the minimum amount of isopropyl alcohol and recrystallised twice more from ethanol to give 0.65 g of the title compound, m.p. dihydrochloride quarter hydrate, m.p. 260°-262° C.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe residue recrystallised from the minimum amount of isopropyl alcohol
  3. customrecrystallised twice more from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-8dae87f3430247cfba9c9f42b16f3681
Quelldatensatz
uspto-grants-1989_02
Patentnummer
US04806552

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