2-Chloroethanol → 2-[(1-methyl-1H-imidazol-2-yl)thio]ethan-1-ol

Temperatur

100 °C

2-Chloroethanol (3 g, 37 mmol) was added to a solution of 2-mercapto-1-methylimidazole (3.45 g, 30 mmol) in 2M aqueous sodium hydroxide solution (30 ml) and the mixture heated at 100° C. for 2 hours. The mixture was allowed to cool and extracted with ethyl acetate. The combined extracts were dried (MgSO4) and the solvent removed by evaporation to give 2-(2-hydroxyethylthio)-1-methylimidazole (3.9 g, 82%). 1H NMR Spectrum: (DMSOd6) 3.04(t, 2H); 3.30(s, 3H); 3.54(t, 2H); 5.00(s, 1H); 6.87(s, 1H); 7.20(s, 1H)

1. temperatureto cool
2. extractionextracted with ethyl acetate
3. dry with materialThe combined extracts were dried (MgSO4)
4. customthe solvent removed by evaporation

ORD-Eintrag

ord-ee8cccb3e1e84cc098673571127cec83

Quelldatensatz

uspto-grants-2001_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06258951B1