8-Methylquinoline-5-carboxylic acid → 8-Methyl-1,2,3,4-tetrahydroquinoline-5-carboxylic acid

HRID 1385044Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1385044
[CH3:1][C:2]1[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1.[H][H]>C(O)C.[Pd]>[CH3:1][C:2]1[C:11]2[NH:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 129507838-Methylquinoline-5-carboxylic acidHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 139517338-Methyl-1,2,3,4-tetrahydroquinoline-5-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

0.1 mol of 8-methylquinoline-5-carboxylic acid was suspended in 1.5 l of ethanol and admixed with 10.0 g of palladium on activated carbon (5%). Over a period of 48 hours, the mixture was reduced in an autoclave at 50° C. using hydrogen (1 bar) (HPLC control). The reaction mixture was then filtered, the filter cake was washed with ethanol and the combined organic filtrates were concentrated.

Aufarbeitung

  1. customwas reduced in an autoclave at 50° C.
  2. filtrationThe reaction mixture was then filtered
  3. washthe filter cake was washed with ethanol
  4. concentrationthe combined organic filtrates were concentrated

Quellen und Nachweise

ORD-Eintrag
ord-d95a369dc23b41f4a78cbb3cc939dca0
Quelldatensatz
uspto-grants-2001_07
Patentnummer
US06262074B1

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