Sodium hydride → Oxolan-2-yl 1-ethenyl-2-oxopyrrolidine-3-carboxylate

HRID 1385437Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1385437
[C:1]([O:5][C:6]([CH:8]1[CH2:12][CH2:11][N:10]([CH:13]=[CH2:14])[C:9]1=[O:15])=[O:7])([CH3:4])(C)C.[H-].[Na+].Cl[CH:19]1[CH2:23]CC[O:20]1>O1CCCC1.C(OCC)C>[O:20]1[CH2:19][CH2:23][CH2:4][CH:1]1[O:5][C:6]([CH:8]1[CH2:12][CH2:11][N:10]([CH:13]=[CH2:14])[C:9]1=[O:15])=[O:7]

Komponenten

6

Edukt 3

HCID 24758Sodium hydrideHCID 178730Furan, 2-chlorotetrahydro-HCID 15389820HCID 15389820, Verbindung

Produkt 1

HCID 54014762Oxolan-2-yl 1-ethenyl-2-oxopyrrolidine-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

8.9 g or 3-(t-butoxycarbonyl)-1-vinyl-2-pyrrolidinone (BCVP) was dissolved in 50 ml of tetrahydrofuran free of moisture. To this solution 1.0 g of sodium hydride and 4.4 g of 2-chlorotetrahydrofuran were added and allowed to react at room temperature for 1 hour. This solution was diluted with diethylether and washed many times with pure water. The organic solvent of the organic phase was evaporated and the residue was subjected to silica gel column chromatography, to obtain 9.3 g of pure 3-(tetrahydrofuranyloxycarbonyl)-1-vinyl-2-pyrrolidinone (hereinafter referred to as “TFVP”). Its chemical structure was determined by IR spectra and NMR.

Aufarbeitung

  1. customto react at room temperature for 1 hour
  2. washwashed many times with pure water
  3. customThe organic solvent of the organic phase was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-6fdd0a8cf79049a5b451472014cfbef5
Quelldatensatz
uspto-grants-2001_07
Patentnummer
US06262222B1

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