Ammonia → 6-Amino-2-fluoronicotinamide

HRID 1386209Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1386209
[F:1][C:2]1[N:10]=[C:9](F)[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[NH3:12].O>C(N)=O>[NH2:12][C:9]1[CH:8]=[CH:7][C:3]([C:4]([NH2:6])=[O:5])=[C:2]([F:1])[N:10]=1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 962WaterHCID 105830482,6-Difluoropyridine-3-carboxamide

Produkt 1

HCID 105348946-Amino-2-fluoronicotinamideAusbeute 31 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 713FormamideLösungsmittel

Versuchsvorschrift

A solution of 2,6-difluoronicotinamide (4.68 g, 0.029 mmol) in dry formamide (30 mL) is saturated with ammonia and allowed to stand at room temperature for 24 h. Water (50 mL) is added and the resultant precipitate is filtered off and washed well with water, to give 6-amino-2-fluoronicotinamide (1.41 g, 31%) mp 236-237° C. 1H NMR (DMSO) δ 7.89 (1H, dd, J=10.4, 8.4 Hz), 7.31, 7.16 (1H, 1H, 2 brs,), 6.93 (2H, brs), 6.36 (1H, dd, J=8.4, 2.4 Hz).

Aufarbeitung

  1. filtrationthe resultant precipitate is filtered off
  2. washwashed well with water

Quellen und Nachweise

ORD-Eintrag
ord-0b811e2d25ba404590ce699068cd1e21
Quelldatensatz
uspto-grants-2001_07
Patentnummer
US06265410B1

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