Water → HCID 2794448, Verbindung

HRID 1386240Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1386240
[C:1](OC(C)(C)C)(=[O:6])[CH2:2][C:3]([CH3:5])=O.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:18]=[C:19]([O:21][CH3:22])[CH:20]=1)[NH2:17].CS(O)(=O)=O.O>C1(C)C(C)=CC=CC=1>[CH3:22][O:21][C:19]1[CH:20]=[C:14]([O:13][CH3:12])[CH:15]=[C:16]2[C:18]=1[C:3]([CH3:5])=[CH:2][C:1](=[O:6])[NH:17]2

Komponenten

6

Edukt 4

HCID 962WaterHCID 6395Methanesulfonic AcidHCID 15538Tert-butyl acetoacetateHCID 663013,5-Dimethoxyaniline

Produkt 1

HCID 2794448HCID 2794448, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7237O-XyleneLösungsmittel

Reaktionsbedingungen

Temperatur
125 °C

Versuchsvorschrift

tert-Butyl acetoacetate (1.58 g) was heated to 120° C. and 3,5-dimethoxyaniline (1.53 g) dissolved in xylene (4 ml) was added. The mixture was heated at 120-130° C. for 20 minutes and then cooled to room temperature. Methanesulfonic acid (2 ml) was added and the mixture was stirred at ambient temperature for 10 minutes. Water (40 ml) was added and the precipitate filtered and dried. Yield 1.31 g (60%).

Aufarbeitung

  1. additionwas added
  2. temperaturecooled to room temperature
  3. filtrationthe precipitate filtered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-7849328713464663824cc3bc1850ea67
Quelldatensatz
uspto-grants-2001_07
Patentnummer
US06265421B1

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