Hydrochloric Acid → 4-(Benzyloxy)-2-(hydroxyimino)-2,3-dihydro-1H-inden-1-one

HRID 1388295

Reaktionsgleichung

Reaktionsgleichung von HRID 1388295
[C:1]1([CH2:7][O:8][C:9]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:10]=2[CH2:11][CH2:12][C:13]3=[O:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:19](OCCC(C)C)=[O:20].Cl>CCOCC>[OH:20][N:19]=[C:12]1[CH2:11][C:10]2[C:14](=[CH:15][CH:16]=[CH:17][C:9]=2[O:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:13]1=[O:18]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 8053Isoamyl NitriteHCID 136161924-(benzyloxy)-2,3-dihydro-1H-inden-1-one

Produkt 1

HCID 714128754-(Benzyloxy)-2-(hydroxyimino)-2,3-dihydro-1H-inden-1-oneAusbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To an ice-cooled solution of 1.91 g (0.008 m) of 4-(phenylmethoxy)-1-indanone in 75 ml of anhydrous ether is added dropwise with stirring 1.2 ml (0.088 m) of isoamyl nitrite while hydrogen chloride is simultaneously bubbled in. After stirring at room temperature for twenty minutes, the reaction mixture is partially concentrated and the solid which separates is filtered to yield 1.83 g (86%) of material sufficiently pure to be used in the next step.

Aufarbeitung

  1. additionis added dropwise
  2. customis simultaneously bubbled in
  3. concentrationthe reaction mixture is partially concentrated
  4. filtrationthe solid which separates is filtered

Quellen und Nachweise

ORD-Eintrag
ord-430e74d3c7b841a39e0c9156e5302765
Quelldatensatz
uspto-grants-1984_02
Patentnummer
US04431647

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