HCID 13186366, Verbindung → HCID 135816716, Verbindung

Reaktionsgleichung

[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:10]=[C:11]([CH2:14][S:15]([NH:18][C:19](=[O:25])[C:20](OCC)=[O:21])(=[O:17])=[O:16])[S:12][CH:13]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].CC(C)([O-])C.[K+]>CN(C)C=O.O>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:10]=[C:11]([C:14]3[S:15](=[O:17])(=[O:16])[NH:18][C:19](=[O:25])[C:20]=3[OH:21])[S:12][CH:13]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Komponenten

Versuchsvorschrift

To a solution of the 2-thiazolylmethyl substituted oxamate intermediate prepared in Step B above (1.0 g., 0.0024 mol) in dimethylformamide (5 ml) was added potassium tert-butoxide (0.55 g, 0.0048 ml) in several portions over 15 minutes. The mixture was stirred at room temperature for 24 hours. After diluting with water (30 ml) and acidifying to congo red indicator paper, a yellow gum (1.1 g.) was obtained. Recrystallization was achieved by dissolving in boiling ether (500 ml), filtering, concentrating to a small volume, and adding petroleum ether. The yield of the title product was 0.3 g., m.p. 250° C. (dec.).