2-Bromoisovaleric acid → N-(2-fluoro-4-chlorophenyl)valine
Reaktionsgleichung
[K].Br[CH:3]([CH:7]([CH3:9])[CH3:8])[C:4]([OH:6])=[O:5].[F:10][C:11]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:12]=1[NH2:13]>>[F:10][C:11]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:12]=1[NH:13][C@H:3]([C:4]([OH:6])=[O:5])[CH:7]([CH3:9])[CH3:8]Komponenten
4
Versuchsvorschrift
N-(2-fluoro-4-chlorophenyl)valine and m-phenoxybenzyl bromide are reacted using the process of Example 42 to yield the m-phenoxybenzyl ester of N-(2-fluoro-4-chlorophenyl)valine, MS m/e 427.1 (M+, 4.1), 200 (100). N-(2-fluoro-4-chlorophenyl)-valine is prepared by heating the potassium salt of α-bromoisovaleric acid and 2-fluoro-4-chloroaniline neat at 130° for about 2 hours.
Quellen und Nachweise
- ORD-Eintrag
- ord-9aa3359cd8034c858f9860eb85b5fe56
- Quelldatensatz
- uspto-grants-1981_01
- Patentnummer
- US04243819
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