Methane → 5-Bromo-N-methanesulfonylpentanamide

HRID 1389412

Reaktionsgleichung

Reaktionsgleichung von HRID 1389412
[CH3:1][S:2]([NH2:5])(=[O:4])=[O:3].[Br:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](Cl)=[O:12].C>C(Cl)Cl>[CH3:1][S:2]([NH:5][C:11](=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7][Br:6])(=[O:4])=[O:3]

Komponenten

5

Edukt 3

HCID 297MethaneHCID 72879MethanesulfonamideHCID 5211735-Bromovaleryl chloride

Produkt 1

HCID 202961415-Bromo-N-methanesulfonylpentanamideAusbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

A mixture of 0.950 g (0.01 mole) of methanesulfonamide and 1.80 g. (0.01 mole) of 5-bromovaleric acid chloride was heated on a steam bath until gas evolution ceased (ca. 5 minutes). The brown reaction mixture was allowed to cool and was dissolved in methylene chloride. The methylene chloride solution was treated with Darco, was filtered, and was diluted with hexane with cooling to afford the white, crystalline N-methanesulfonyl-5-bromovaleramide weighing 2.22 g. (86.0% yield) which melted at 88°-89°.

Aufarbeitung

  1. custom(ca. 5 minutes)
  2. temperatureto cool
  3. filtrationwas filtered
  4. additionwas diluted with hexane
  5. temperaturewith cooling

Quellen und Nachweise

ORD-Eintrag
ord-ccda27c2fe5c41eea6cfe8975ef8b3a8
Quelldatensatz
uspto-grants-1981_01
Patentnummer
US04244887

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