HCID 12902850, Verbindung → HCID 12902851, Verbindung

HRID 1389741Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1389741
[Br:1][C:2]1[CH:17]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:15]=[CH:14][C:3]=1[O:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O>O>[Br:1][C:2]1[C:3]2[O:4][CH:5]=[C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:14]=2[CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:17]=1

Komponenten

3

Edukt 1

HCID 12902850HCID 12902850, Verbindung

Produkt 1

HCID 12902851HCID 12902851, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 156 g. of the product of step A and 1 kg. of polyphosphoric acid is heated at 100° C. for seven days. The reaction mixture is poured into 5 liters of water and stirred, then extracted with 2 liters of chloroform. The dried extracts are treated with decolorizing charcoal, then evaporated. The residue is chromatographed on silica gel, eluting with carbon tetrachloride. The residue is triturated with hexane to provide 7-bromo-3,5-diphenylbenzofuran as a pale yellow solid. The structural assignment is supported by infrared and nuclear magnetic resonance spectral analysis.

Aufarbeitung

  1. additionA mixture of 156 g
  2. extractionextracted with 2 liters of chloroform
  3. additionThe dried extracts are treated with decolorizing charcoal
  4. customevaporated
  5. customThe residue is chromatographed on silica gel
  6. washeluting with carbon tetrachloride
  7. customThe residue is triturated with hexane

Quellen und Nachweise

ORD-Eintrag
ord-52f7e16721504327860f6c8e605bf17e
Quelldatensatz
uspto-grants-1981_01
Patentnummer
US04246179

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