Hydrogen Bromide → HCID 23455899, Verbindung

HRID 1389986Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1389986
C(OC([C:6]1[O:7][C:8]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([CH2:22][C:23]([O:25]CC)=[O:24])=[CH:18][CH:17]=3)=[CH:12][C:9]=2[C:10]=1[CH3:11])=O)C.Br>C(O)(=O)C>[CH3:11][C:10]1[C:9]2[CH:12]=[C:13]([C:16]3[CH:21]=[CH:20][C:19]([CH2:22][C:23]([OH:25])=[O:24])=[CH:18][CH:17]=3)[CH:14]=[CH:15][C:8]=2[O:7][CH:6]=1

Komponenten

4

Edukt 2

HCID 260Hydrogen BromideHCID 12902869HCID 12902869, Verbindung

Produkt 1

HCID 23455899HCID 23455899, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A solution of 17 g. of the product of step A in 100 ml. of acetic acid with 35 ml. of 48 percent hydrobromic acid is heated at reflux for three hours, then poured into ice water. This mixture is extracted into dichloromethane, and the extracts are dried to provide 4-(3-methylbenzofuran-5-yl)phenylacetic acid. This intermediate is esterified by heating with a trace of sulfuric acid in ethanol. The product is purified by chromatography on silica gel, eluting with 20 percent dichloromethane in carbon tetrachloride to provide ethyl 4-(3-methylbenzofuran-5-yl)phenylacetate.

Aufarbeitung

  1. temperatureat reflux for three hours
  2. extractionThis mixture is extracted into dichloromethane
  3. customthe extracts are dried

Quellen und Nachweise

ORD-Eintrag
ord-6ff3910ed89147418a01288f1b24736d
Quelldatensatz
uspto-grants-1981_01
Patentnummer
US04247469

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