Acetic Anhydride → N(2,5-DIME-PYRROL-1-YL)-6-($-MORPHOL)-3-PYRIDAZ-

HRID 1390006Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1390006
[CH3:1][C:2]1[N:3]([NH:8][C:9]2[N:10]=[N:11][C:12]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[CH:13][CH:14]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22]>N1C=CC=CC=1>[C:21]([N:8]([N:3]1[C:4]([CH3:7])=[CH:5][CH:6]=[C:2]1[CH3:1])[C:9]1[N:10]=[N:11][C:12]([N:15]2[CH2:16][CH2:17][O:18][CH2:19][CH2:20]2)=[CH:13][CH:14]=1)(=[O:23])[CH3:22]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 711434-(6-((2,5-Dimethylpyrrol-1-yl)amino)-3-pyridazinyl)morpholine

Produkt 1

HCID 23276131N(2,5-DIME-PYRROL-1-YL)-6-($-MORPHOL)-3-PYRIDAZ-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

A mixture of 6 g (22 m mol) of N-(2,5-dimethyl-1H-pyrrol-yl)-6-morpholino-3-pyridazineamine, 30 ml of acetic anhydride, and 6 ml of pyridine is heated for one hour at 110° C. The reaction mixture is evaporated to dryness under vacuum and the oily residue is dissolved in 150 ml of ethyl acetate. The organic solution is washed first with 50 ml of an aqueous solution of sodium bicarbonate and then with 50 ml of water.

Aufarbeitung

  1. customThe reaction mixture is evaporated to dryness under vacuum
  2. dissolutionthe oily residue is dissolved in 150 ml of ethyl acetate
  3. washThe organic solution is washed first with 50 ml of an aqueous solution of sodium bicarbonate

Quellen und Nachweise

ORD-Eintrag
ord-77a61adbb99741d4b65194677054727a
Quelldatensatz
uspto-grants-1981_01
Patentnummer
US04247551

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