Benzoyl chloride → 3-Benzoyloxy-5-methylisoxazole

HRID 1390042

Reaktionsgleichung

Reaktionsgleichung von HRID 1390042
[OH:1][C:2]1[CH:6]=[C:5]([CH3:7])[O:4][N:3]=1.[C:8](Cl)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(N(CC)CC)C>[C:8]([O:1][C:2]1[CH:6]=[C:5]([CH3:7])[O:4][N:3]=1)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Komponenten

4

Edukt 2

HCID 7412Benzoyl chlorideHCID 24781Hymexazol

Produkt 1

HCID 124150073-Benzoyloxy-5-methylisoxazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

3-Hydroxy-5-methylisoxazole was reacted with benzoyl chloride in the presence of triethylamine to give 3-benzoyloxy-5-methylisoxazole, which was then reacted with N-bromosuccinimide, to give 3-benzoyloxy-5-bromomethylisoxazole. This was reacted with disodium thioglycolate to give 3-hydroxyisoxazol-5-ylmethylthioacetic acid, which was treated with diphenyldiazomethane to give the benzhydryl ester.

Quellen und Nachweise

ORD-Eintrag
ord-784b205c021847b0b97909951156c164
Quelldatensatz
uspto-grants-1981_01
Patentnummer
US04247548

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